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Curriculum Vitae

Amanda Bischoff-Grethe

Laboratory of Cognitive Imaging                                   

VA San Diego Healthcare System            

3350 La Jolla Village Drive, M/C 151B       

San Diego, CA 92161              

tel: (858) 552-8585 x2480

fax: (858) 642-1458

e-mail: agrethe@ucsd.edu

EDUCATION

University of SOUTHERN California, Los Angeles, CA

PhD in Computer Science, 1998            Advisor: Dr. Michael A. Arbib

NORTHEASTERN UNIVERSITY, Boston, MA

MS in Computer Science, 1991

Lehigh UNIVERSITY, Bethlehem, PA

BS in Electrical Engineering, 1989

RESEARCH EXPERIENCE

University of California San Diego, San Diego, CA September 2003 to Present

Assistant Project Scientist in the Department of Psychiatry

Research focus includes the study of reward mechanisms in the basal ganglia during motor control in control subjects and psychostimulant addicted patients.  Methodologies include using fMRI and computational modeling techniques. 

University of California San Diego, San Diego, CA  July 2002 to August 2003

Postdoctoral Fellow in the Department of Psychiatry

Research focus includes the study of reward mechanisms in the basal ganglia during motor control in control subjects and psychostimulant addicted patients.  Methodologies include using fMRI and computational modeling techniques.  In addition, involved with the Biomedical Informatics Research Network (BIRN) project; duties include instruction in morphometric software, the testing of deidentification methods for structural MR images, and functional data analyses.

Dartmouth College, Hanover, NH February 2000 to June 2002

Research Associate in the Department of Psychological and Brain Sciences

Researching sequencing and sequence learning in normal subjects using fMRI of basal ganglia and supplementary motor area, and the role of cerebellum in motor behavior, particularly response reassignment (changes of motor set).

Emory University, Atlanta, GA October 1998 to January 2000

Markey Postdoctoral Fellow in the Department of Neurology

Continued modeling of the basal ganglia and supplementary motor area during learning and the performance of sequential arm movements under both normal and parkinsonian conditions.  Explored sequencing and sequence learning in normal subjects using fMRI.  Performed data analysis on neuronal data collected from Parkinson’s disease patients during pallidotomy.

University of Southern California, Los Angeles, CA January 1998 to August 1998

Human Brain Project (HBP) Postdoctoral Fellow in the Department of Computer Science

Developed database for the development, research, and publication of computational models and summary data as part of the Human Brain Project.  Continued basal ganglia modeling with respect to sequential arm movements in both normal and parkinsonian subjects.

University of Southern California, Los Angeles, CA     1993 to 1998

Office of Naval Research (ONR) Research Assistant 1993 to 1996

Human Brain Project (HBP) Research Assistant 1996 to 1998

Modeled the basal ganglia and its involvement in arm movement in both normal and parkinsonian subjects under the direction of Dr. Michael A. Arbib.  Also involved in the development of object-relational databases for the storage of computational models as part of the Human Brain Project.

INSERM Unité 94, Bron, France                                      March to April 1995

Visited the lab of Dr. Marc Jeannerod for one month.  Observed several experiments in progress, including primate studies of basal ganglia, prefrontal cortex, and cingulate, and human kinematic studies involving reach and grasp.  Had several discussions with members of the research facility concerning motor control issues.

TEACHING EXPERIENCE

University of Southern California, Los Angeles, CA     1991 to 1993

Teaching Assistant in the Department of Computer Science

Professional Affiliations

Cognitive Neuroscience Society

Institute of Electronics and Electrical Engineers

International Neural Network Society

Society for Neuroscience

Women in Neuroscience

RESEARCH SUPPORT

The Role of Dopamine Reward Mechanisms in Motor Control

Principal Investigator: Amanda B. Grethe, Ph.D.

Agency: National Institute on Drug Abuse (NIDA)

Type: K01 (DA015499)

Period: 9/03 – 6/08

Total Direct: $497,974

Major goals: To explore the relationship between reward mechanisms and motor control in the basal ganglia using computational modeling and fMRI in normal controls and recently habilitated methamphetamine addicts.

PUBLICATIONS

Fennema-Notestine, C., Ozyurt, I. B., Clark, C. P., Morris, S., Bischoff-Grethe, A., Bondi, M. W., Jernigan, T. L., Fischl, B., Segonne, F., Shattuck, D. W., Leahy, R. M., Rex, D. E., Toga, A. W., Zou, K. H., the Morphometry BIRN, and Brown, G. G., In Press, Quantitative evaluation of automated skull stripping methods applied to contemporary and legacy images: Effects of diagnosis, bias correction, and slice location, Human Brain Mapping.

Drummond, S.P.A., Bischoff-Grethe, A., Dinges, D.F., Ayalon, L., Mednick, S.C., and Meloy, M. J., 2005, The neural basis of the psychomotor vigilance task, Sleep, 28:1059-1068.

Bischoff-Grethe, A., Goedert, K, Willingham, D.T., and Grafton, S. T., 2004, Neural substrates of response-based sequence learning using fMRI, Journal of Cognitive Neuroscience, 16: pp. 127-138.

Bischoff-Grethe, A., Ivry, R. B., and Grafton, S. T., 2002, Cerebellar involvement in response reassignment rather than attention, Journal of Neuroscience, 22: pp. 546-553.

Bischoff-Grethe, A., Martin, M., Mao, H., and Berns, G. S., 2001, The context of uncertainty modulates the subcortical response to predictability, Journal of Cognitive Neuroscience, 13: pp. 986-993.

Bischoff-Grethe, A., Proper, S. M., Mao, H., Daniels, K. A., and Berns, G. S., 2000, Conscious and unconscious processing of nonverbal predictability in Wernicke’s area, Journal of Neuroscience, 20: pp. 1975-1981.

Bischoff, A., 1998, Modeling the basal ganglia in the control of arm movements, Doctoral Dissertation, University of Southern California.

Bischoff, A., Arbib, M. A., and Winstein, C., J., 1997, Modeling the basal ganglia in a reciprocal aiming task, Proceedings of the Fourth Annual Joint Symposium on Neural Computation, 7: pp. 20–27.

Arbib, M. A., Bischoff, A., Fagg, A. H., and Grafton, S. T., 1995, Synthetic PET: Analyzing large-scale properties of neural networks, Human Brain Mapping, 2: pp. 225–233 (Cover Article).

Bischoff, A., and Wang, P. S. P., 1992, Handwritten digit recognition using neural networks, Proceedings SPIE Intelligent Robots and Computer Vision, 1608: pp. 436–447.

BOOK CHAPTERS

Bischoff-Grethe, A., Crowley, M. G., and Arbib, M. A., 2003, Movement inhibition and next sensory state prediction in the basal ganglia, The Basal Ganglia VI, Graybiel, A. M., DeLong, M. R., and Kitai, S. T., Eds., Kluwer Publishing, New York, pp. 267-277.

Bischoff-Grethe, A. and Arbib, M. A., 2001, Brain imaging and synthetic PET, Computing the Brain: A Guide to Neuroinformatics, Arbib, M. A. and Grethe, J. S., Eds., Academic Press, San Diego, pp. 103-113.

Bischoff-Grethe, A., Spoelstra, J., and Arbib, M. A., 2001, Brain models on the web, Computing the Brain: A Guide to Neuroinformatics, Arbib, M. A. and Grethe, J. S., Eds., Academic Press, San Diego, pp. 297-317.

Arbib, M. A. and Bischoff-Grethe, A., 2001, Summary databases and model repositories, Computing the Brain: A Guide to Neuroinformatics, Arbib, M. A. and Grethe, J. S., Eds., Academic Press, San Diego, pp. 287-296.

INVITED TALKS

Bischoff-Grethe, A., September 2003, “Introduction to Computing,” Informatics Tools for Scientific Discovery and Collaboration Workshop, University of Illinois – Chicago, Chicago, IL.

Bischoff-Grethe, A., July 2001, “Computational Neuroscience – Lab,” Summer Institute in Cognitive Science, Dartmouth College, Hanover, NH.

ABSTRACTS

Bischoff-Grethe, A., Buxton, R. B., Fleisher, A., and Brown, G. G., November 2005, Basal ganglia activation in a monetary reward and reward expectancy task, Program No. ###.##, 2005 Abstract Viewer and Itinerary Planner, SFN, Washington, DC.

Brown, G., Pieper, S., Martone, M., Aucoin, N., Joyner, A., Bischoff-Grethe, A., Torvik, V., and FIRST BIRN, October 2004, The query atlas: A brain referenced knowledge discovery tool, Program No. 1032.2, 2004 Abstract Viewer and Itinerary Planner, SFN, San Diego, CA.

Morris, S., Brown, G., Glover, G., Foland, L., Bischoff-Grethe, A., Liu, T., Ozyurt, B., Turner, T., and FIRST BIRN, October 2004, The stability of primary sensory activation in fMRI across sites: Initial calibrations, Program No. 694.19, 2004 Abstract Viewer and Itinerary Planner, SFN, San Diego, CA.

Bischoff-Grethe, A., Fischl, B., Ozyurt, I.B., Morris, S., Brown, G. G., Fennema-Notestine, C., Clark, C. P., Bondi, M. W., Jernigan, T. L., and the Human Morphometry BIRN (www.nbirn.net), June 2004, A technique for the deidentification of structural brain MR images, Human Brain Mapping, Budapest, Hungary (Published in Neuroimage, Vol. 22 Supplement 1, WE 346 and online http://www.meetingassistant.com/ohbm/meeting_plan/ohbm_mtg_index_search.php).

Jovicich, J., Pieper, S., Miller, M., Gollub, R., Rex, D., Bischoff-Grethe, A., Buckner, R., Krishnan, R., and the Brain Morphometry BIRN, November 2003, Biomedical informatics research network: integrating multi-site neuroimaging data acquisition, data, sharing and brain morphometric processing, NIH Biomedical Information Science and Technology Initiative Consortium, Bethesda, MD.

Fennema-Notestine, C., Ozyurt, I. B., Brown, G. G., Clark, C. P., Morris, S., Bischoff-Grethe, A., Bondi, M. W., Jernigan, T.L., and the Human Brain Morphometry BIRN (www.nbirn.net), November 2003, Bias correction, pulse sequence, and extent of neurodegeneration influence the performance of automated skull-stripping methods, Program No. 863.23, 2003 Abstract Viewer/Itinerary Planner, SFN, New Orleans, LA.

Bischoff-Grethe, A., Hazeltine, E., Bergren, L., Ivry, R. B., and Grafton, S. T., March 2003, The effects of reward feedback and expectancy on subcortical areas in an associative learning task, CNS, New York, NY.

Bischoff-Grethe, A., Newman-Norlund, R., and Grafton, S. T., April 2002, Functional substrates of emerging awareness of sequence structure: A fMRI study, CNS, San Francisco, CA (Published in Journal of Cognitive Neuroscience, p. 149).

Shin, J. C., Bischoff-Grethe, A., Ivry, R. B., and Grafton, S. T., April 2002, Functional integration of temporal and spatial structure in a sequence learning task, CNS, San Francisco, CA (Published in Journal of Cognitive Neuroscience, pp. 138-139).

Bischoff-Grethe, A., Goedert, K. M., Willingham, D. B., and Grafton, S. T., November 2001, Perceptual vs. response-based learning in a SRT task using fMRI, SFN, San Diego, CA (Published in Soc. Neurosci. Abstr.).

Bischoff-Grethe, A., Ivry, R. B., and Grafton, S. T., June 2001, Cerebellar involvement in motor remapping rather than attention, Human Brain Mapping, Brighton, UK (Published in NeuroImage, Vol. 13, No. 6, Part 2, p. S300).

Bischoff-Grethe, A., Martin, M., Mao, H., and Berns, G. S., November 2000, History dependent modulation of subcortical responses to motor entropy, SFN, New Orleans, LA (Published in Soc. Neurosci. Abstr., Vol. 26,).

Bischoff-Grethe, A., Martin, M., Mao, H., and Berns, G. S., June 2000, History dependent modulation of subcortical responses to motor entropy, Human Brain Mapping, San Antonio, TX.

Bischoff-Grethe, A., Proper, S. M., Mao, H., and Berns, G. S., November 1999, Neuronal correlates of informational uncertainty: An fMRI study, SFN, Miami, FL (Published in Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 102).

Bischoff-Grethe, A. and Arbib, M. A., November 1998, Modeling the basal ganglia: Support for a theory on its involvement in motor control, SFN, Los Angeles, CA (Published in Soc. Neurosci. Abstr., Vol. 24, Part 2, p. 1653).

Alexander, A., Bischoff-Grethe, A., and Arbib, M. A., November 1998, Neural simulation language: A modeling simulation tool for learning brain function, SFN, Los Angeles, CA (Published in Soc. Neurosci. Abstr., Vol. 24, Part 1, p. 246).

Bischoff-Grethe, A., Ovsiannikov, I., McNeill, T. H., and Arbib, M. A., November 1998, An on-line database for neuroscience information retrieval and computational modeling, SFN, Los Angeles, CA (Published in Soc. Neurosci. Abstr., Vol. 24, Part 1, p. 244).

Bischoff-Grethe, A., Crowley, M. G., and Arbib, M. A., October 1998, Movement inhibition and next sensory state prediction in the basal ganglia, Sixth Triennial Meeting International Basal Ganglia Society, Brewster, MA.

Crowley, M. G., Bischoff, A., and Arbib, M. A., June 1998, Basal ganglia function: Sensory expectation and the suppression of unwanted states, Workshop on Neural Modeling of Brain and Cognitive Disorders, University of Maryland College Park.

Bischoff, A., and Arbib, M. A., November 1997, Modeling the role of basal ganglia and supplementary motor area in sequential arm movements, SFN, New Orleans, LA (Published in Soc. Neurosci. Abstr., Vol. 23, Part 1, p. 466).

Bischoff, A., Arbib, M. A., and Winstein, C. J., November 1996, A computational model of the role of the basal ganglia in a reciprocal aiming task, SFN, Washington, DC (Published in Soc. Neurosci. Abstr., Vol. 22, Part 3, p. 2028).

SKILLS

Computer languages: Basic, Pascal, FORTRAN, C, C++, Prolog, Lisp, Scheme, SQL

Computer systems: DOS, MAC OS, UNIX, Windows OS

Database Systems: Illustra, dBASE IV, Informix, Microsoft Access

Neural simulation environments: NSL

Statistical Packages: Excel, Matlab, SPM[96/99/2], FSL, SPSS

MR Scanner Systems: Philips Gyroscan 1.5T, General Electric 1.5T and 3T, Varian 3T        

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last edited: 07/28/2007