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Phase
I fMRI Research Study for Healthy Volunteers
Dr.
Martin Paulus and his associates from the Department of Psychiatry at
UCSD in La Jolla are studying the effects of taking either
1) an
investigational drug called GSK561679,
2)
Lorazepam (Ativan) or
3) a
placebo (inactive pill with no medication in it),
and then
having a functional Magnetic Resonance Imaging (fMRI) brain scan.
Study drug GSK561679 is being tested in anxiety and depression research,
and Ativan is an FDA approved medication for anxiety. For this
research study, we are asking healthy males to perform simple computer
tasks while we are recording their brain activity using fMRI. We use
these computer tasks to examine areas of the brain that process
emotion.
We are
looking for healthy male subjects between the ages of 18 to 50 years.
If you want to participate, you cannot
have any of the following:
·
major medical
problems
·
any history of psychiatric illness
·
a history of problems with alcohol or drugs
If you are
interested in participating, the following will happen:
-
There will be a pre-study
screening visit which takes about 3 hours and you will be reimbursed
$50.00 for this visit.
-
If you qualify and are
interested, you will be asked to complete the computer tasks in a
Magnetic Resonance Imaging machine (which is like a big plastic
donut that makes some noise) at 5 different visits after receiving
either study drug GSK561679, Lorazepam (Ativan) or a placebo
(inactive pill with no medication in it) . Each visit will take
about 8 hours, and you will be reimbursed $100.00 for each
visit, and get a picture of your brain. You will be reimbursed
$150.00 after you have completed a post-study follow up visit.
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